DISORDERS OF THE HEMOSTASIS SYSTEM IN ACUTE RESPIRATORY DISEASES OF THE LUNG.
Abstract
The lungs actively participate in the processes of coagulation and fibrinolysis. In particular, lung tissue is a rich source of factors for the coagulation and anti-coagulation systems of the blood. Thromboplastin, heparin, tissue plasminogen activator, prostacyclins, thromboxane A2, are synthesized in the lungs. Fibrinolysis occurs in the lungs, with the formation of fibrin degradation products (FDP). The lungs are capable of extracting from the bloodstream not only fibrin, but also its degradation products, which are excessively formed during DIC. Therefore, platelet-neutrophil interactions play an important role in recruiting neutrophils to the lungs during lung injury and ARDS.
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